Urination in the human is decreased by
Muscarinic agonists
Muscarinic antagonists
AChase inhibitors
Nicotinic agonists
Spider venom
Urination in the human is decreased by
Muscarinic agonists
Muscarinic antagonists
AChase inhibitors
Nicotinic agonists
Spider venom
A 5-year-old child becomes ill while visiting relatives who have a farm in Arkansas. His symptoms include severe abdominal cramps with vomiting and diarrhea and profuse lacrimation and salivation. Pupillary constriction is marked. The most likely cause is exposure to
Herbicides
Antifreeze
Lead-based paint
Insecticides
Rat poison
The activation of muscarinic receptors in bronchiolar smooth muscle is associated with
Activation of adenylyl cyclase
Decrease in cAMP formation mediated by G-proteins
Increase in IP3 and DAG
Inhibition of protein kinase C
Opening of Na+/K+ cation channels
Ganglion blocking agents are of little clinical value today but they are important drugs to know for solving cardiovascular drug problems because they can block
All muscarinic receptors
All nicotinic receptors
All autonomic reflexes
The direct actions of drugs on blood vessels
The direct actions of drugs on the heart
An 11-year-old boy was brought to the ER by some of his friends because he “started going crazy” after eating seeds from a plant while “trying to get high.” The boy was incoherent; his skin was hot and dry. His pupils were dilated and unresponsive to light. Blood pressure was 180/105, pulse 150, and rectal temp 40°C. The presumptive diagnosis was drug toxicity due to the ingestion of a compound similar to
Cannabis
Digoxin
Mescaline
Phencyclidine
Scopolamine
Thermoregulatory sweat glands in the body utilize what type of pathway?
Cholinergic nerves and muscarinic receptors
Adrenergic nerves and alpha-1 receptors
Adrenergic nerves and beta-2 receptors
Cholinergic nerves and NM receptors
Neurohumorally-released epinephrine
Following pretreatment with a muscarinic receptor blocking agent, the IV administration of norepinephrine is likely to result in
↑ HR and ↑ BP
↑ HR and ↓ BP
↓ HR and ↓ BP
↓ HR and ↑ BP
no effect on HR, but ↑ BP
A colleague with myasthenia gravis wants you to assist him to the ER because he is experiencing muscle weakness and has found it difficult to titrate his drug dosage because he has had the “flu.” You note that he has a slight temperature, shallow respirations, and a gray-blue skin pallor. What would be the most appropriate drug to give to your colleague at this time?
Albuterol
Edrophonium
Propranolol
Physostigmine
Scopolamine
Neostigmine differs from pilocarpine in having effects on
Bladder tone
Bowel motility
Heart rate
Salivary glands
Skeletal muscle
A 37-year-old woman has blurred, double vision 8 hours after eating home-preserved peppers. Six hours later, she has dysphagia, dry mouth and eyes, progressive weakness of the arms and legs, and urinary retention. She is awake and alert. Which of the following is the most likely mechanism of these adverse effects?
Antagonism of muscarinic receptors
Antagonism of nicotinic receptors
Inhibition of acetylcholine release
Inhibition of cholinesterase activity
Inhibition of G proteins
The first-aid center has received a victim of a traffic accident diagnosed with closed displaced fracture of the middle third of the thigh. For repositioning of the bone fragments the patient received 10 mL of 2% Dithylinum solution intravenously, which resulted in the prolonged period of apnoea and muscle relaxation. What enzyme is deficient, resulting in such pharmacogenetic enzymopathy?
Pseudocholinesterase
Uridine diphosphate glucuronyltransferase
Glucose 6-phosphate dehydrogenase
Methemoglobin reductase
N-acetyltransferase
During gastric resection the patient received mixed anesthesia with Tubocurarin chloride muscle relaxant; to restore spontaneous respiration the patient received Proserin. What pharmacological group does this drug belong to?
Cholinesterase inhibitors
Angiotensin-converting-enzyme inhibitors
Calcium channel blockers
Muscarinic antagonists
Muscarinic agonists
A 47-year-old man developed intestinal colic against the back ground of essential hypertension. In this situation it would be most efficient to arrest the colic by administering drugs of the following group:
Myotropic antispasmodics
Anticholinesterase agents
Sympathomimetics
M-cholinomimetics
Adrenomimetics
A 36-year-old patient has been administered a depolarizing muscle relaxant during a surgery. Name this drug:
Dithylinum
Proserin
Pipecuronium bromide (Arduan)
Diazepam
Aminazine
A patient after disrupted cerebral circulation has developed paralysis. Choose the anticholinesterase drug to be prescribed in this case:
Proserin
Cordiamin
Aceclidine
Methacin
Hexamethonium (Benzohexonium)
A patient was prescribed atropine sulfate to treat intestinal colic. What concomitant disease can be a contraindication for this drug?
Glaucoma
Bronchial asthma
Sinus bradycardia
Hypotension
Vertigo
At the 2-3 day after the gastric resection the patient’s intestinal peristalsis failed to restore. What should the patient be prescribed to stimulate the function of his gastrointestinal tract?
Proserin
Platyphyllin
Cyclodol (Trihexyphenidyl)
Atropine
Dithyline (Suxamethonium chloride)
The first-aid center has received a victim of a traffic accident diagnosed with closed displaced fracture of the middle third of the thigh. For repositioning of bone fragments the patient received 10ml of 2% dithylinum solution intravenously, which resulted in prolonged period of apnoea and muscle relaxation.What enzyme is deficient, resulting in such pharmacogenetic enzymopathy?
Pseudocholinesterase
Uridine diphosphate glucuronyltransferase
Glucose6-phosphate dehydrogenase
Methemoglobinreductase
N-acetyltransferase
After a nephrectomy the patient developed enteroparesis. What cholinergic agent with anticholinesterase action should be prescribed in this case?
Proserin
Carbacholine
Aceclidine
Pilocarpine
Acetylcholine
A patient, who has been taking β- adrenergic blockers, developed a bronchial spasm. What group of bronchodilators should be chosen to stop the bronchial spasm?
Myotropic antispasmodics
β-adrenergic blockers
Indirect adrenergic agonists
Muscarinic cholinomimetic agents
Cholinesterase inhibitors
A patient complains of dizziness, thirst, difficult swallowing, and impaire dvision of close objects. Objectively: respiratory rate is increased, pupils are dilated, general agitation, talkativeness, though the speech is indistinct. BP is 110/70 mm Hg, heart rate is 110/min. Given symptoms can indicate overdosage of the following drug:
Atropine
Morphine
Ephedrine
Aminazine
Caffeine
A patient has been given atropine sulfate for rapid relief of spastic colon symptoms. The use of this drug is contraindicated during the followng disease:
Glaucoma
Bronchial asthma
Bradycardia
Hypotension
Gastriculcer
Analeptical remedyof reflective type from the H-cholinomimetics group was given to the patient for restoration of breathing after poisoning with carbon monoxide. What medicine was prescribed to the patient?
Atropine sulphate
Adrenalin hydrochloride
Mesaton
Pentamin
Lobeline hydrochloride
What drug causes dilation of the pupil and paralysis of accommodation when instilled in the eyes?
Prozerin (Nestigmine)
Pilocarpine hydrochloride
Atropine sulfate
Galantamine hydrobromide
Furacilin (Nitrofural)
Tubocurarine chloride was used during dislocation reduction in a patient. Soon the patient developed overdose symptoms. What drug should be used to eliminate these symptoms?
Omeprazole
Furosemide
Prozerin (Neostigmine)
Morphine
Dithylin (Suxamethonium)
A man was hospitalized with abdominal pain and profuse salivation, sweating, and tears. Examination detects miosis. The day before, he was treating plants with a solution of an insecticidal substance without wearing personal protective equipment. The substance that has caused the poisoning in this case belongs to:
Organochlorine compounds
Copper salts
Nicotinic cholinomimetics
Nitrates
Anticholinesterase agents
A 48-year-old woman has been diagnosed with Raynaud syndrome (a spasm of peripheral blood vessels) and prescribed an adrenotropiс agent. What group does this drug belong to?
β1-blockers
α-blockers
β2-blockers
β1-adrenergic agonists
α/β-adrenergic agonists
An ophthalmologist used a 1% Mesaton solution for the diagnostic purpose (pupil dilation for eye-ground examination). What is the cause of mydriasis induced by the drug?
Activation of α2 adrenoreceptors
Block of α1 adrenoreceptors
Activation of β1 adrenoreceptors
Activation of α1 adrenoreceptors
Activation of M-cholinoreceptors
During a surgery with the use of Hygronium the patient had an abrupt fall in blood pressure. Blood pressure can be normalized by the representatives of the following drug group:
α-adrenergic agonists
α-blockers
Ganglionic blockers
M-cholinergic agents
N-cholinergic agents
A patient ill with bronchial asthma didn’t inform his doctor that he had attacks of stenocardia. Doctor administered him a medication, which taking resulted in less frequent attacks of bronchial asthma, but stenocardia attacks became more frequent. What medication was administered?
Isoproterenol (isadrin)
Salbutamol
Aminophylline
Cromolyn sodium
Fenoterol
A patient with coronary artery disease was admitted to the cardiological department. For stenocardia prevention a drug from the group of β-adrenoceptor blockers was administered. What drug is it?
Atropine sulfate
Metoprolol
Morphine hydrochloride
Oxytocin
Furosemide
A 68-year-old patient consults a cardiologist, complaining of high arterial blood pressure, pain in the heart egion, intermittent pulse. Prescribe the β1-adrenoreceptor blocker for the treatment of the described pathology:
Morphine hydrochloride
Nootropil
Fenoterol
Benzylpenicillin
Metoprolol
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